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After a Second Shot or a Booster Shot

Side effects after the second shot may be more intense than the ones experienced after the first shot. These side effects are normal signs that the body is building protection and should go away within a few days.

So far, reactions reported after getting a booster shot are similar to those after the two-dose or single-dose primary shots. Fever, headache, fatigue, and pain at the injection site were the most commonly reported side effects, and overall, most side effects were mild to moderate. However, as with the two-dose or single-dose primary shots, serious side effects are rare but can occur.

When to Call the Doctor

Side effects can affect you or your child’s ability to do daily activities, but they should go away in a few days.

In most cases, discomfort from pain or fever is a normal sign that the body is building protection. Contact a doctor or healthcare provider:

  • If the redness or tenderness where the shot was given gets worse after 24 hours

  • If the side effects are worrying or do not seem to be going away after a few days

If you or your child get a COVID-19 vaccine and you think you or they might be having a severe allergic reaction after leaving the vaccination site, seek immediate medical care by calling 911. Learn more about COVID-19 vaccines and rare severe allergic reactions.

If You Have No Side Effects

Reactions after getting a COVID-19 vaccine can vary from person to person. Most people in clinical trials experienced only mild side effects, and some of them had no side effects at all. Those people still had a strong immune response to the vaccine. Vaccination protects you from severe COVID-19 infection whether or not you have side effects after vaccination.

Reporting Side Effects

After vaccination, enroll yourself or your child in v-safe. V-safe allows you to share how you or your child feel after COVID-19 vaccination using your smartphone. V-safe uses text messaging and web surveys to provide personalized health check-ins after COVID-19 vaccination. V-safe also reminds you to get additional COVID-19 doses if needed. It is free, easy-to-use, and completely confidential. Learn more about v-safe.

If you would like to report an adverse event, side effect, or reaction from the COVID-19 vaccine, please use the Vaccine Adverse Event Reporting System (VAERS)external icon. Learn more about VAERS.

What to Expect after Getting a COVID-19 Vaccine

Fact sheet for healthcare workers to give after vaccination. Other Languages:

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